Interleukin-24 (IL-24, also called Mob-5 or Mda-7) is an important member of the IL-10 family of cytokines discovered by Dr. Peng Liang’s laboratory at Vanderbilt University and it signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2 (References 1-5, see below). His group used comprehensive Differential Display screening and identified over two dozen genes regulated by ras oncogene. They focused on a gene encoding a novel secreted protein designated IL-24, which is expressed by activated T cells as well as other cell types transformed by ras oncogenes. Through a series of biochemical studies including GenHunter's AP-TAG technology, Dr. Liang's group demonstrated that ras oncogenes could not only induce the expression of IL-24, but also its receptor(s) in the transformed cells.

Both IL-24 and IL-20 share the identical heterodimeric receptors. Upon binding to its receptors, IL-24 induces rapid activation of Stat-1 and Stat-3 transcription factors (2) in the JAK-SAT signaling pathway, which appear to play a role in cell survival and proliferation (4). Under physiological conditions, the major sources of IL-24 are the activated monocytes and T helper 2 cells (2-4), whereas the major IL-24 target tissues, based on the receptor expression pattern, are non-hematopoietic in origin and include skin (3-4), lung, and reproductive tissues. IL-24 is part of a complex cytokine network implicated in epidermal functions (3), tissue repairs/wound healing (5), autoimmune diseases such as psoriasis (4), and cancer (6). Thus, the IL-24 signaling pathway may offer a potential therapeutic target for treatment of cancer and other conditions.

GenHunter is now offering 5 monoclonal antibodies against human IL-24, 1 polyclonal antibody against human IL-24, 1 polyclonal antibody against rat IL-24, plus other controls. We also offer 2 human IL-20R2 monoclonal antibodies and 1 fusion protein.

IL-24 and IL-20 products available:

We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), AP (alkaline phosphatase).

References:

1. Wang, M. and Liang, P.: Interleukin-24 and its receptors. (2005) Immunology. 114:166–170. https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2005.02094.x
2. Wang, M. et al.: Interleukin-24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. (2002) J. Biol. Chem. 277:7341-7347. https://www.jbc.org/article/S0021-9258(19)82292-5/pdf
3. He, M. and Liang, P.: IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. (2010) J. Immunol. 1, 184: 1793-1798. https://journals.aai.org/jimmunol/article/184/4/1793/38783/IL-24-Transgenic-Mice-In-Vivo-Evidence-of
4. Liu, X. et al: A broad blockade of signaling from the IL-20 family of cytokines potently attenuates collagen-induced arthritis. (2016) J Immunol. 197:3029-3037. https://journals.aai.org/jimmunol/article/197/8/3029/105897/A-Broad-Blockade-of-Signaling-from-the-IL-20
5. Liu, S. et al: A tissue injury sensing and repair pathway distinct from host pathogen defense. (2023) Cell. 186:2127–2143. https://www.cell.com/cell/fulltext/S0092-8674(23)00328-8
6. Zhang, R. et al: Identification of a novel ligand-receptor pair constitutively activated by ras oncogene. (2000) J. Biol. Chem. 275:24436-24443. https://www.jbc.org/article/S0021-9258(19)62189-7/fulltext

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.