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- Human IL-20R2 Neutralizing Antibody, Mouse Monoclonal [K501N-100 or K501N-025]
Human IL-20R2 Neutralizing Antibody, Mouse Monoclonal [K501N-100 or K501N-025]
Product Description
Interleukin-20 (IL-20) is a member of the IL-10 family of cytokines discovered by ZymoGenetics Inc (Reference 1, see below). Like IL-24, IL-20 signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2 (1-2). Upon binding to its receptors, both IL-20 and IL-24 induce rapid activation of Stat-1 and Stat-3 transcription factors in the JAK-SAT signaling pathway, which appear to play a role in cell survival and proliferation (1, 3). Both IL-20 and IL-24 transgenic mice manifest similar phenotypes with neonatal lethality, epidermal hyperplasia, and abnormality in keratinocyte differentiation (1, 4). Abnormality in expression of these cytokines has been implicated in autoimmune diseases such as psoriasis and arthritis. Blockade of both IL-20 and IL-24 biological functions by soluble IL-20R2-Fc fusion protein was able to markedly inhibit the disease phenotype in animal models (3).
GenHunter is now offering 2 monoclonal antibodies against human IL-20R2 (a binding antibody and one that is a neutralizing & binding antibody) as well as Recombinant Human IL-20R2-Fc fusion protein. We also offer many products for human IL-24 (see links below): 5 monoclonal antibodies against human IL-24, 1 polyclonal antibody against human IL-24, 1 polyclonal antibody against rat IL-24, plus other controls.
IL-20R2 & IL-24 products available:
| Product description | Volume | Applications |
Cat. No. |
Click to Order |
|
Human IL-20R2 Neutralizing Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K501N-025 K501N-100 |
Order |
|
Human IL-20R2 Binding Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K501B-025 K501B-100 |
Order |
| 25 & 100 µg |
|
MP203-025 MP203-100 |
Order | |
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Human IL-24 Antibody (Clone 2B5) Mouse monoclonal (Ascites) |
100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-2B5 | Order |
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Human IL-24 Antibody (Clone 12D3) Mouse monoclonal (Ascites) |
25 & 100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-12D3-025 K101-12D3-100 |
Order |
|
Human IL-24 Antibody (Clone 18F4-C1) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-18F4-025 K101-18F4-100 |
Order |
|
Human IL-24 Antibody (Clone 22H8-G9) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-22H8-025 K101-22H8-100 |
Order |
|
Human IL-24 Antibody (Clone 27D6-F5) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-27D6-025 K101-27D6-100 |
Order |
|
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K102 | Order |
|
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K201 | Order |
| IL-24-His (human) Western blot control | 100 µL | Western | K301 | Order |
| IL-24-His (rat) Western blot control | 100 µL | Western | K302 | Order |
|
Serum-free, hIL-24 at ~1µg/mL |
1 & 5 mL |
Receptor activation Working conc.: 50 ng/mL |
K401 K402 |
Order |
IL-20R2 references:
- Blumberg, H. et al: Interleukin 20: Discovery, receptor identification, and role in epidermal function. (2001) Cell. 104:9-19. https://www.cell.com/cell/fulltext/S0092-8674(01)00187-8
- Wang, M. et al: Interleukin-24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. (2002) J. Biol. Chem. 277:7341-7347. https://www.jbc.org/article/S0021-9258(19)82292-5/pdf
- Liu, X. et al: A broad blockade of signaling from the IL-20 family of cytokines potently attenuates collagen-induced arthritis. (2016) J Immunol. 197:3029-3037. https://journals.aai.org/jimmunol/article/197/8/3029/105897/A-Broad-Blockade-of-Signaling-from-the-IL-20
- He, M. and Liang, P.: IL-24 transgenic mice: In vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. (2010) J. Immunol. 184: 1793-1798. https://journals.aai.org/jimmunol/article/184/4/1793/38783/IL-24-Transgenic-Mice-In-Vivo-Evidence-of
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
| Antibody Specifications | |
| Antibody Name |
Human IL-20R2 Neutralizing Antibody, Mouse Monoclonal |
| Clone No. | 38A3-B8 |
| Class | Mouse Monoclonal, purified |
| Catalog No / SKU | K501N-100 (for 100 µg) or K501N-025 (for 25 µg) |
| Specificity | Human IL-20R2 |
| Binding / Neutralizing mAb | Neutralizing mAb (NAb) |
| Volume | 25 or 100 ug |
| Provided as | Liquid |
| Applications | Neutralizing antibody: EC50 = 690 ng/mL ELISA: antigen binding affinity EC50 = 9.7 ng/mL Western Blot at 1:1000 - 1:2000 |
| Concentration | ~1 mg/mL |
| Purification | G protein affinity purified, >99% determined by HPLC |
| Storage conditions | Store at -20°C long term, Avoid freeze / thaw cycle |
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Documents
IL-20R2 & IL-24 products available:
| Product description | Volume | Applications |
Cat. No. |
Click to Order |
|
Human IL-20R2 Neutralizing Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K501N-025 K501N-100 |
Order |
|
Human IL-20R2 Binding Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K501B-025 K501B-100 |
Order |
| 25 & 100 µg |
|
MP203-025 MP203-100 |
Order | |
|
|
|
|||
|
Human IL-24 Antibody (Clone 2B5) Mouse monoclonal (Ascites) |
100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-2B5 | Order |
|
Human IL-24 Antibody (Clone 12D3) Mouse monoclonal (Ascites) |
25 & 100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-12D3-025 K101-12D3-100 |
Order |
|
Human IL-24 Antibody (Clone 18F4-C1) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-18F4-025 K101-18F4-100 |
Order |
|
Human IL-24 Antibody (Clone 22H8-G9) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-22H8-025 K101-22H8-100 |
Order |
|
Human IL-24 Antibody (Clone 27D6-F5) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-27D6-025 K101-27D6-100 |
Order |
|
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K102 | Order |
|
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K201 | Order |
| IL-24-His (human) Western blot control | 100 µL | Western | K301 | Order |
| IL-24-His (rat) Western blot control | 100 µL | Western | K302 | Order |
|
Serum-free, hIL-24 at ~1µg/mL |
1 & 5 mL |
Receptor activation Working conc.: 50 ng/mL |
K401 K402 |
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
![Human IL-24 Antibody, Mouse Monoclonal (Clone 18F4-C1) [K101-18F4-100 or K101-18F4-025]](https://cdn10.bigcommerce.com/s-b9lqur1b/products/176/images/798/K101-18F4-Western_Blot__27935.1709938849.270.190.jpg?c=2)
![Human IL-20R2 Binding Antibody, Mouse Monoclonal [K501B-100 or K501B-025]](https://cdn10.bigcommerce.com/s-b9lqur1b/products/180/images/837/K501B-Western_Blot__47497.1711401173.270.190.jpg?c=2)
![Recombinant Human IL-20R2-Fc Fusion Protein [MP203-100 or MP203-025]](https://cdn10.bigcommerce.com/s-b9lqur1b/products/208/images/986/MP203_Recombinant_Human_IL-20R2-Fc_Fusion_Protein_SEC-HPLC__58806.1718935386.270.190.jpg?c=2)
