| GenHunter receives NIH SBIR Phase I grant |
New DD-based technology for analyzing non-poly(A) RNA
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May 1, 2008: GenHunter Corporation received a Phase I SBIR award from the National Institutes of Health (NIH), for the commercialization of a new technology called NPA-DD. The grant title is "Analyzing Non-poly(A) RNA Transcripts with Differenital Display". Products based on this technology should be released soon....more
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| GenHunter Granted New U.S. Patent Covering Trimerization of Secreted Proteins |
New Trimer-Tag technology
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 | | Trimeric receptor bound to ligand |
U.S. patent No.: 7,268,116
Title: Methods and Compositions For Producing Secreted Trimeric Receptor Analogs And Biologically Active Fusion Proteins
Issue Date: September 11, 2007
GenHunter Corporation has been granted a new U.S. patent (7,268,116) covering the design and expression of any secreted therapeutic protein in disulfide bond-linked homo-trimeric forms. The technology dubbed Trimer-Tag takes advantage of the C-prodomains of collagen proteins, which are capable of efficient self-trimerization. Collagens are the most abundant and naturally occurring proteins secreted by mammals, including humans. The Trimer-Tag technology offers a new platform for the creation of trimeric soluble receptors and antibodies for more efficient targeting of corresponding disease-causing homotrimeric ligands, such as TNF family of cytokines and HIV gp120. Co...more
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| State-of-the-art DD technology featured in recent publications |
In Nature Methods and Nature Protocols
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Nature Methods publications:
Recognizing the tremendous and continuing impact of DD technology on biomedical research in the past 15 years, Nature Methods featured the DD methodology as a Classic Protocol. The accompanying commentary by Michael Eisenstein traced back to the days when Drs. Arthur Pardee and Peng Liang invented the ingenious method. The two inventors also offered their perspectives on DD versus DNA microarrays.
To read the "Classic Protocol", Click here.
Complete reference:
Differential display polymerase chain reaction. Nature Methods. 2006, 3:325-326.
To read Eisenstein's commentary, Click here.
Complete reference:
Eisenstein, M.: A look back: putting differences aside. Nature Methods. 2006, 3:324.
Nature Protocols publication:
With continued interest and demand in DD technology for the most accurate analysis of differential gene expression, GenHunter has compiled a step-by-step protocol for its state-of-the-art DD technology in both fluorescent digital and radioactive formats. This most up-to-date and authoritative DD methodology cited...more
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