| GenHunter Granted New U.S. Patent Covering Trimerization of Secreted Proteins |
New Trimer-Tag technology
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 | | Trimeric receptor bound to ligand |
U.S. patent No.: 7,268,116
Title: Methods and Compositions For Producing Secreted Trimeric Receptor Analogs And Biologically Active Fusion Proteins
Issue Date: September 11, 2007
GenHunter Corporation has been granted a new U.S. patent (7,268,116) covering the design and expression of any secreted therapeutic protein in disulfide bond-linked homo-trimeric forms. The technology dubbed Trimer-Tag takes advantage of the C-prodomains of collagen proteins, which are capable of efficient self-trimerization. Collagens are the most abundant and naturally occurring proteins secreted by mammals, including humans. The Trimer-Tag technology offers a new platform for the creation of trimeric soluble receptors and antibodies for more efficient targeting of corresponding disease-causing homotrimeric ligands, such as TNF family of cytokines and HIV gp120. Co...more
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| DD technology featured in new PNAS paper and other Nature journals |
Killin, a new p53 tumor-suppressor gene target, discovered by FDD
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 | | Killin identified by DD |
Dr. Peng Liang’s laboratory at Vanderbilt has identified a long sought-after p53 tumor-suppressor target gene, which they dubbed “Killin” for its ability to cause cell death by arresting DNA replication. Dr. Liang is the co-inventor of DD and his laboratory worked with GenHunter to perform a saturation Fluorescent Differential Display (FDD) screen of p53 target genes and identified Killin as a unique mediator of p53 in S-phase check point control and apopotosis.
To read this April 2008 PNAS publication, click here.
Legend for figure at right:
RFP-Killin inhibits DNA replication in vivo. The RFP-Killin in-frame fusion protein (Upper) or RFP control (Lower) expression vectors were ...more
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| GenHunter receives NIH SBIR Phase I grant |
New DD-based technology for analyzing non-poly(A) RNA
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 | | NPA-DD |
May 1, 2008: GenHunter Corporation received a Phase I SBIR award from the National Institutes of Health (NIH), for the commercialization of a new technology called NPA-DD. The grant title is "Analyzing Non-poly(A) RNA Transcripts with Differenital Display". Products based on this technology ...more
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